The Buffalo News newsroom is the hub of writing, photographing and designing for each day’s paper. With nearly 200 staff members, The News has by far the largest news-gathering organization of any media in upstate New York, helping to produce the largest newspaper in the state outside New York City. The News has won three Pulitzer prizes, and each year wins many statewide awards in competition with the state's biggest newspapers.

The newsroom is staffed from 6 a.m. to 2 a.m. Departments include Local news, Sports, Business, Life & Arts, Photo, Graphics and the News library. Staff members who report to Editor and Vice President Margaret Sullivan include reporters, photographers, page designers, copy, layout and content editors, columnists, researchers and supervising editors. But The News is ranked by a competing publication as the most powerful institution in Western New York. Taking that responsibility seriously, the paper’s editors emphasize local news, strong enterprising reporting and in-depth investigative journalism.

In 2004-05 the paper underwent a complete, in-house redesign. That “anchored” all the main news and classified sections in the same order and with the same elements inside each one every day. It returned the Picture Page to the paper’s lineup and assigned a half-page every day to a color weather package.

The News’ stated editorial goal is: ”We want to be a paper that consistently executes important journalism, presented effectively and with style; that engages readers and makes itself indispensable to them; and that is shot through with intelligence, sophistication and humanity.”